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KMID : 0378019890320120023
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New Medical Journal
1989 Volume.32 No. 12 p.23 ~ p.29
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Sleep Substances
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Abstract
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Sleep may be the one of the most integrative functions in animals and it appears likely that sleep may be controlled and regulated through both neural and humoral inforrr.ations. During past decade, since the discovery of DSIP (Delta- Sleep- Inducing -Peptide) which was the first candidate of sleep substance, vast body of researches were conducted to evidence the presence of sleep substance in vain. Historically, many sleep researchers have sougyt `the single sleep factor´ and the single sleep center´, but neither `the factor´ nor ´the center´ was found.
Instead, many sleep factors are identified and it has been realized that many areas of the brain are involved in sleep regulation. It is unlikey that one sleep factor regulates all the aspects of sleep but that multiple non-specific factors such as hormones, immune sue tances, pyrogens, anabolic and metabolic products, and circadian rhythm-related substances are dynamically and interactingly participated in the process of sleep regulation.
In this regards, it might be concluded that sleep results from the collective interactions of many sleep factors on several neuronal sets, not from the specific pattern of a single n uronal set.
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